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DICOM Data Room

Share DICOM, NIfTI, and pathology imaging — under NDA, with audit trails.

A secure data room for de-identified medical imaging diligence: DICOM studies, NIfTI volumes, pathology whole-slide imaging, DICOM-RT plans, and DICOM-SR reports. NDA gates before any folder loads. Dynamic watermarks on every imaging thumbnail and clinical report. Screenshot protection across desktop and mobile. Granular visitor-group permissions and per-viewer audit trails. $40 per admin per month on Peony Business — unlimited storage, unlimited rooms, unlimited counterparties.

What is a DICOM data room?

A DICOM data room is a virtual data room engineered for secure external sharing of de-identified medical imaging — DICOM (.dcm) studies, DICOMDIR multi-study directories, NIfTI (.nii, .nii.gz) neuroimaging volumes, pathology whole-slide imaging (.svs, .ndpi, .mrxs, .scn), DICOM-RT radiotherapy plans, and DICOM-SR structured reports — with external counterparties under NDA. The same external-review workflow as a traditional VDR (NDA gates, granular permissions, page-level analytics, audit trails, Q&A) but engineered for medical-imaging file sizes where individual studies and pathology slides routinely exceed 1-2 GB and full diligence packages reach hundreds of gigabytes.

Three things break when biotech, medtech, pharma, CRO, and healthcare M&A teams use generic tools to share medical imaging. First, cloud storage (Box, SharePoint, OneDrive, Google Drive, Dropbox) lacks NDA gates and dynamic watermarks tied to viewer identity — fine for internal collaboration, inadequate for $50M+ external diligence where imaging-asset leaks are consequential. Second, clinical-workflow systems (PACS, RIS, imaging core labs) are built for radiologist read workflows and IRB-aligned trial execution, not deal-stage external diligence with bidder-track permissions. Third, per-page legacy VDRs (Datasite, Firmex, Intralinks) charge $0.60+ per page on raw imaging data, rendering 50GB of DICOM as 40,000-100,000 'pages' at $24,000-$60,000 in per-page fees alone — a workflow misalignment for imaging-heavy life-sciences diligence.

Peony Business at $40 per admin per month shares de-identified medical imaging inside the data room with NDA gates before any folder loads, dynamic watermarks stamping every imaging thumbnail, every WSI preview, and every clinical report with the viewer's name, email, IP, and timestamp, screenshot protection across desktop and mobile, and visitor-group permissions segregating scientific diligence, regulatory diligence, commercial diligence, and IP counsel inside the same room. Your team handles DICOM tag stripping and PHI removal at upload per your own HIPAA, GDPR, or IRB workflow — Peony is the secure external-distribution layer.

Which medical imaging formats does Peony support?

DICOM (.dcm) — single-file medical imaging studies
DICOMDIR — multi-study directory packages
DICOM-SR — structured clinical reports
NIfTI (.nii, .nii.gz) — neuroimaging volume format
NRRD (.nrrd, .nhdr) — research imaging volumes
Pathology WSI: .svs (Aperio), .ndpi (Hamamatsu)
Pathology WSI: .mrxs (3DHISTECH), .scn (Leica)
DICOM-RT — radiotherapy plans, structures, dose
Cine MP4 / MOV — exported 4D imaging clips
PDF clinical reports, IND/IDE/510(k) submissions

DICOM and pathology WSI files preview as thumbnails inside the data room with frame-burned watermarks. Full-resolution download is configurable per visitor group, gated behind NDA, with dynamic watermarks and per-viewer audit-trail logging.

Who uses a DICOM data room?

Biotech imaging biomarker diligence

Series B-stage diligence with imaging endpoint datasets. NDA-gated DICOM, NIfTI volumes, and clinical reports.

AI radiology M&A and licensing

Training-set DICOM, validation imaging, model performance reports, FDA submissions for medtech buyers.

Pharma imaging-AI partnering

BD diligence on imaging-biomarker startups. Pathology WSI, DICOM training data, scientific deep-dive.

Diagnostic imaging chain M&A

Outpatient imaging operator sales: modality fleet, payer mix, technologist credentials, workflow samples.

Pathology lab acquisitions

Whole-slide imaging (.svs, .ndpi, .mrxs), CLIA accreditation, CAP inspections, payer contracts.

CRO sponsor handover

End-of-trial deliverables: de-identified DICOM follow-up studies, study reports, regulatory packages.

How do I share DICOM files securely with diligence counterparties?

  • De-identify before upload. Strip DICOM tags and remove PHI per your HIPAA, GDPR, or IRB workflow. Peony is the external-distribution layer; de-identification stays inside your compliance pipeline.
  • Watermark every imaging thumbnail. Dynamic watermarks stamp viewer name, email, IP, and timestamp on top of every preview — a screen recording or camera-of-screen still traces back to the specific viewer.
  • Block screenshots. Desktop and mobile capture attempts blocked and logged into the per-viewer audit trail.
  • NDA-gate every folder. Counterparties sign your CDA via integrated e-signatures before any imaging folder loads. No NDA, no access.
  • Audit every view. Page-level analytics show which buyer streams accessed which imaging modality for how long — exportable for negotiation prioritization or post-close reps-and-warranties evidence.

When is Peony NOT the right fit for medical imaging?

Use a PACS / RIS instead (Sectra, GE Centricity, Philips IntelliSpace, Agfa, MedDream) if the workflow is clinical radiologist reads, in-hospital report distribution, or HL7-integrated radiology operations. Peony is the deal-and-diligence layer, not the clinical-workflow layer.

Use an imaging core lab / clinical trial portal (Bioclinica, ICON Imaging Core Lab, Calyx, Medidata Imaging) if the workflow is in-trial central reading, site QC, automated query routing, or IRB-aligned audit trails on every read. Use the imaging core lab during trial execution; use a data room at trial close for sponsor handover and post-trial diligence.

Use a clinical-grade DICOM cloud (Ambra Health, Life Image, Nucleus.io, Blackford) for ongoing clinical exchange between providers, telerad routing, or AI-inference pipelines on live patient data. Peony is for de-identified deal-stage diligence, not live clinical exchange.

Use a genomics-specific platform (Terra, DNAnexus, Seven Bridges) for genomic pipeline execution (BAM/CRAM/VCF processing, joint-calling, GWAS). Peony shares final reports and curated dataset packages, not pipeline runtime.

For very small one-off transfers (single de-identified study to one investigator once), a watermarked file shared via personalized link may be enough. Don't pay for a data-room subscription you'll use once.

"Peony has been great for sharing documents with investors, employees, and customers. It's easy to use, good value, and new features are constantly being added. Definitely recommend!"
Y Combinator
EH

Ed Harris

Founder & CEO, Ligo Bio (YC S24)

Frequently asked questions

I'm a CFO at a 40-person clinical-stage biotech raising a $60M Series B — we have 80GB of DICOM imaging biomarker data, NIfTI brain MRIs, and clinical reports. What's the right room for investor diligence?

For your 40-person clinical-stage biotech raising $60M Series B, Peony Business at $40/admin/month handles 80GB+ of de-identified DICOM imaging biomarker studies, NIfTI brain MRI volumes, pathology slides, IND filings, CMC documentation, and clinical reports inside one NDA-gated room. Upload at full resolution — no per-GB surcharges, no forced file splitting. Each prospective investor signs your CDA before any folder loads via integrated e-signatures. Dynamic watermarks stamp every page (including imaging thumbnails and reports) with the investor's name, email, and timestamp. Configure visitor groups so lead investors see the full IND and CMC package while diligence counsel sees only the IP and regulatory subset. Page-level analytics show which lead investors are deepest into the imaging biomarker dataset versus the financial model — useful for prioritizing $60M-round follow-up. Datasite quotes $25K-$60K for life-sciences diligence rooms; Peony's 1-2 admin team pays $480-$960/year flat. Note: Peony is the secure-distribution layer — your team de-identifies DICOM tags and removes PHI before upload per your own HIPAA/IRB workflow.

I'm head of corp dev at a 200-person medtech device company with an FDA-cleared AI radiology product — we're being acquired and the buyer wants 120GB of training-set DICOM studies, validation imaging, and 510(k) submissions. How do we share?

For your 200-person medtech in M&A diligence, Peony Business at $40/admin/month handles 120GB+ of de-identified DICOM training-set studies, NIfTI volumes, validation imaging, model performance reports, 510(k) submission packages, FDA correspondence, and clinical trial data inside one room with no per-GB surcharges. Configure visitor groups so the buyer's commercial diligence team sees revenue and customer files while their regulatory and AI/ML diligence team sees the model card, training-set metadata, validation studies, and FDA submissions. Dynamic watermarks stamp every page with the buyer-side reviewer's identity. Screenshot protection blocks captures across desktop and mobile. Audit trails log every view with timestamps, exportable for post-close reps-and-warranties evidence. Datasite and Intralinks quote $40K-$120K for medtech diligence at this scale; Peony's 4-admin deal team pays $1,920/year flat across as many concurrent diligence streams as you run. Your regulatory team handles DICOM de-identification and PHI removal at upload per your own QMS.

I'm head of BD at a top-15 pharma evaluating a $400M imaging-AI licensing deal — counterparty sent us 50GB of DICOM training studies and pathology WSI files. What workflow makes sense?

For your top-15 pharma's $400M imaging-AI licensing diligence, Peony Business at $40/admin/month handles 50GB+ of DICOM training studies and pathology whole-slide imaging (.svs, .ndpi, .mrxs) inside an NDA-gated room. Your BD team configures visitor groups: scientific diligence sees model performance and validation imaging; legal sees IP and contracts; finance sees commercial assumptions. Dynamic watermarks stamp every page (including imaging thumbnails) with the reviewer's name, IP, and timestamp — useful when licensing-deal disputes turn on whether your team accessed specific datasets. NDA gates require the counterparty to sign before any folder loads. Page-level analytics show which scientific reviewers spent time on which imaging modalities — useful for prioritizing scientific diligence calls. Many pharma BD teams default to Box Enterprise for licensing diligence; Box has no NDA gates, no dynamic watermarks, and no page-level analytics on PDFs or imaging thumbnails. Peony's flat $40/admin/month covers your entire BD team across as many concurrent licensing evaluations as you run.

I'm a project manager at a 300-person CRO running a Phase III imaging-endpoint trial — we need to share 200GB of de-identified DICOM follow-up studies with the sponsor's medical reviewers. Should we use a clinical trial portal or a data room?

For your 300-person CRO running a Phase III imaging-endpoint trial, the right answer is usually both, used for different stages. A clinical trial imaging portal (Bioclinica, ICON Imaging Core Lab, Calyx) handles the in-trial workflow — central reading, site QC, automated query routing, IRB-aligned audit trails on every read. Use the imaging core lab for trial execution. Use a data room when the deliverable becomes a curated diligence package — sponsor-handover at trial close, regulatory submission packages, post-trial licensing or M&A diligence, or sponsor due-diligence on a follow-on indication. Peony Business at $40/admin/month handles 200GB+ of de-identified DICOM follow-up studies, NIfTI volumes, and study reports for sponsor handover with NDA gates, dynamic watermarks, screenshot protection, and visitor-group permissions segregating sponsor medical from regulatory from commercial. The CRO does not pay per-GB; the sponsor does not pay per-page. Use the right tool for the right stage.

I'm CFO at a $300M diagnostic imaging chain (15 outpatient centers) preparing to sell to a hospital network — we have 60GB of operational documentation, modality fleet records, and de-identified workflow imaging. What should the data room look like?

For your $300M diagnostic imaging chain sale, Peony Business at $40/admin/month handles 60GB+ of operational documentation: modality fleet records (CT, MRI, ultrasound, mammography service histories), payer contracts, referral patterns, technologist credentials, accreditation files, de-identified workflow imaging samples, financial statements, real estate leases, and corporate records inside one NDA-gated room. Configure visitor groups so the buyer's commercial diligence sees patient-volume and payer-mix files; their clinical operations diligence sees modality and technologist records; their real estate team sees lease files; their tax counsel sees corporate structure. Dynamic watermarks stamp every page with the buyer-team reviewer's identity. Page-level analytics show which buyer streams are deepest into which subset — useful for prioritizing the 60-90 day post-LOI confirmatory diligence. Peony's flat $40/admin/month is structurally aligned with mid-market healthcare M&A timelines; legacy VDRs charge per-page on the 5,000+ page diligence index, easily $30K-$80K for a deal this size.

I'm founder of a 12-person AI radiology startup raising $8M seed — we have 25GB of de-identified DICOM training data, model performance reports, and clinical validation imaging. Investors want to see it. How do we share without leaking the training set?

For your 12-person AI radiology startup raising $8M seed, Peony Business at $40/admin/month handles 25GB of de-identified DICOM training data, NIfTI volumes, model performance reports, validation imaging, and FDA pre-submission correspondence inside an NDA-gated room. Each prospective investor signs your CDA via integrated e-signatures before any folder loads. Dynamic watermarks stamp every imaging thumbnail and report page with the investor's name, email, and timestamp — useful when training-set provenance is the asset. Screenshot protection blocks captures. No download access on the imaging subset (download permissions configured per visitor group). Audit trails log every view with timestamps. Investors see what you choose to show; nothing leaves the platform. Page-level analytics show which lead investors are deepest into the model performance versus the founding team materials — useful for prioritizing follow-up. Most pre-seed and seed-stage AI startups default to Google Drive or Notion; neither has NDA gates, dynamic watermarks, or audit trails on imaging files. Peony Business at $40/admin/month is structurally cheaper than the cost of a single training-set leak.

I'm a managing partner at a 25-person pathology lab being acquired by a larger reference lab — we have 40GB of pathology WSI samples (.svs, .ndpi), accreditation documentation, and CLIA records. Can a data room handle whole-slide imaging?

Yes. For your 25-person pathology lab acquisition, Peony Business at $40/admin/month handles 40GB+ of pathology whole-slide imaging (.svs Aperio, .ndpi Hamamatsu, .mrxs 3DHISTECH), de-identified case samples, CLIA accreditation files, CAP inspection reports, technologist credentialing, payer contracts, and operational records inside one NDA-gated room. Pathology WSI files are large — single slides routinely exceed 1-2 GB at full resolution. Peony's flat $40/admin/month does not surcharge per-GB. Buyer pathology diligence reviewers preview WSI thumbnails and download under audit-trail logging; commercial diligence sees revenue and contracts; CLIA diligence sees accreditation and QC files. Dynamic watermarks stamp every page with the buyer-side identity. Screenshot protection blocks captures across desktop and mobile. Page-level analytics show which buyer streams are deepest into which subset. Datasite and Intralinks per-page pricing makes pathology WSI economically painful; Peony does not.

I'm a corp dev director at a 4,000-bed hospital network spinning out our outpatient imaging service line as a standalone $180M asset — we need to share imaging-volume data, payer contracts, modality records, and de-identified case samples with PE buyers. What's the right room?

For your hospital network's $180M imaging service-line spin-out, Peony Business at $40/admin/month handles imaging-volume operational data, payer contracts, modality fleet records, technologist credentials, de-identified case samples, real estate, financial statements, and corporate records inside one NDA-gated room. Configure visitor groups so each PE buyer's commercial diligence sees patient-volume and payer-mix; their clinical-ops diligence sees modality and technologist files; their real estate team sees lease records; their tax and legal counsel sees corporate structure. Dynamic watermarks stamp every page with the buyer-team reviewer's identity. NDA gates require each PE bidder to sign before any folder loads. Audit trails log every view with timestamps — exportable for the post-close reps-and-warranties evidence. PE buyers comparing 4-6 spin-out targets are running concurrent diligence streams; Peony's flat $40/admin/month structurally aligns with the seller running a controlled multi-bidder process. Datasite quotes $40K-$100K for spin-outs at this scale; Peony's 3-admin deal team pays $1,440/year flat across as many concurrent bidder rooms as you create.

NDA-gate. Watermark always. Audit every view.

Set up your DICOM data room in under 5 minutes. NDA gates, dynamic watermarks, and screenshot protection on Peony Business at $40/admin/month.

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